저널명 : Bulletin of the Korean Chemical Society, 37, 2019-2024 (2016) 
저자 : Hyun Ji Park, Sung Chul Yang and Jaebum Choo* 
기타사항 :  

Abstract

We report a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) kit for the rapid diagnosis of influenza virus A. Influenza virus A is highly infectious and causes acute respiratory diseases. Therefore, it is important to diagnose the virus early to prevent a pandemic and to provide appropriate treatment to the patient and vaccination of high-risk individuals. Conventional diagnostic tests, including virus cell culture and real-time polymerase chain reaction, take longer than 1 day to confirm the disease. In contrast, a commercially available rapid influenza diagnostic test can detect the infection within 30 min, but it is hard to confirm viral infection using only this test because of its low sensitivity. Therefore, the development of a rapid and simple test for the early diagnosis of influenza infection is urgently needed. To resolve these problems, we developed a SERS-based LFA kit in which the gold nanoparticles in the commercial rapid kit were replaced with SERS-active nano tags. It is possible to quantitatively detect the influenza virus A with high sensitivity by measuring the enhanced Raman signal of these SERS nano tags on the LFA strip. The limit of detection (LOD) using our proposed SERS-based LFA kit was estimated to be 1.9 × 104 PFU/mL, which is approximately one order of magnitude more sensitive than the LOD determined from the colorimetric LFA kit.


Download PDF = Click Attachment, please.

List of Articles
제목 저널명 저자 기타사항

2017 Quantum Dot–based Molecularly Imprinted Polymers on Three-Dimensional Origami ... file

저널명 ACS Sensors, 2, 243-250 (2017) 

저자 Bowei Li, Zhong Zhang, Ji Qi, Na Zhou, Song Qin, Jaebum Choo* and Lingxin Chen* 

기타사항  

2017 Spectroscopic measurements of interactions between hydrophobic 1-pyrenebutyric... file

저널명 Colloids and Surfaces A, 518, 295-303 (2017) 

저자 Nguyen Hoang Ly, Thanh Danh Nguyen, Thanh Lam Bui, Sangyeop Lee, Jaebum Choo, Sang-Woo Joo* 

기타사항  

2017 Raman spectrum identification based on the correlation score using weighted ... file

저널명 Analyst, 142, 380-388 (2017) 

저자 Jun-Kyu Park, Aaron Park, Si Kyung Yang, Sung-June Baek*, Joonki Hwang and Jaebum Choo* 

기타사항  

2017 Simultaneous Detection of Dual Nucleic Acids Using a SERS-based Lateral Flow... file

저널명 Analytical Chemistry, 89, 1163-1169 (2017) 

저자 Xiaokun Wang, Namhyun Choi, Ziyi Cheng, Juhui Ko, Lingxin Chen*, and Jaebum Choo* 

기타사항  

2017 Optical nanoprobes for ultrasensitive immunoassay file

저널명 Analytical Chemistry, 89, 124-137 (2017) 

저자 Xiuli Fu, Lingxin Chen* and Jaebum Choo* 

기타사항  

2017 Interfacial structures of 1-methyladenine, 3-methyladenine, 7-methyladenine, and... file

저널명 Journal of Molecular Structure, 1128, 215-220 (2017) 

저자 Dinh Bao Nguyen, Sang-Woo Joo* and Jaebum Choo* 

기타사항  

2017 Quantitative analysis of thyroid-stimulating hormone (TSH) using SERS-based later... file

저널명 Sensor and Actuators B, 240, 358-364 (2017) 

저자 Suji Choi, Joonki Hwang, Sangyeop Lee, Dong Woo Lim, Hoodon Joo, and Jaebum Choo* 

기타사항  

2016 Streptavidin-triggered signal amplified fluorescence polarization for analysis o... file

저널명 Analyst, 141, 6499-6502 (2016) 

저자 Jae-Won Choi, Byung-Gwan Jo, Andrew deMello*, Jaebum Choo* and Hak Yong Kim* 

기타사항  

2016 Early Diagnosis of Influenza Virus A Using SERS-based Lateral Flow Assay file

저널명 Bulletin of the Korean Chemical Society, 37, 2019-2024 (2016) 

저자 Hyun Ji Park, Sung Chul Yang and Jaebum Choo* 

기타사항  

2016 Surface-Enhanced Raman Scattering and Fluorescence-Based Dual Nanoprobes for ... file

저널명 Journal of Biomedical Nanotechnology, 12, 1938-1951 (2016) 

저자 Hongdeok Jang, Eun Young Hwang, Yongshin Kim, Jaebum Choo, Jihoon Jeong, and Dong Woo Lim* 

기타사항  


XE Login