저널명 : Lab on a Chip, 18, 3631-3637 (2018) 
저자 : Gregor Holzner, Ying Du, Xiaobao Cao, Jaebum Choo, Andrew deMello* and Stavros Stavrakis* 
기타사항 :  

Abstract

In recent years, high-speed imaging has become increasingly effective for the rapid analysis of single cells in flowing environments. Single cell imaging methods typically incorporate a minimum magnification of 10× when extracting sizing and morphological information. Although information content may be significantly enhanced by increasing magnification, this is accompanied by a corresponding reduction in field of view, and thus a decrease in the number of cells assayed per unit time. Accordingly, the acquisition of high resolution data from wide field views remains an unsolved challenge. To address this issue, we present an optofluidic flow cytometer integrating a refractive, microlens array (MLA) for imaging cells at high linear velocities, whilst maximizing the number of cells per field of view. To achieve this, we adopt an elasto-inertial approach for cell focusing within an array of parallel microfluidic channels, each equipped with a microlens. We characterize the optical performance of the microlenses in terms of image formation, magnification and resolution using both ray-tracing simulations and experimental measurements. Results demonstrate that the optofluidic platform can efficiently count and magnify micron-sized objects up to 4 times. Finally, we demonstrate the capabilities of the platform as an imaging flow cyclometer, demonstrating the efficient discrimination of hB and Jurkat cells at throughputs up to 50000 cells per second.


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List of Articles
제목 저널명 저자 기타사항

2018 An optofluidic system with integrated microlens arrays for parallel imaging flo... file

저널명 Lab on a Chip, 18, 3631-3637 (2018) 

저자 Gregor Holzner, Ying Du, Xiaobao Cao, Jaebum Choo, Andrew deMello* and Stavros Stavrakis* 

기타사항  

2018 Reinforcement Learning for Dynamic Microfluidic Control file

저널명 ACS Omega, 3, 10084-10091 (2018) 

저자 Oliver Dressler, Philip Howes, Jaebum Choo and Andrew deMelllo* 

기타사항  

2018 Fluoropolymer Coated PDMS Microfluidic Devices for Application in Organic ... file

저널명 Chemistry - A European Journal, 24, 12078-12083 (2018) 

저자 T. Yang, J. Choo, S. Stavrakis* and A. deMello* 

기타사항  

2018 Sensitive and Reproducible Immunoassay of Multiple Mycotoxins Using Surface-En... file

저널명 Small, 1801623 (2018). 

저자 Xiaokun Wang, Sung-Gyu Park, Juhui Ko, Xiaofei Xiao, Vincenzo Giannini, Stefan A. Maier, Dong-Ho Kim,* Jaebum Choo* 

기타사항 Frontispiece 

2018 Plasmonic Colorimetric Sensors Based on Etching and Growth of Noble Metal ... file

저널명 Biosensors & Bioelectronics, 114, 52-65 (2018) 

저자 Z. Zhang, H. Wang, Z. Chen, X. Wang, J. Choo* and L. Chen* 

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2018 Highly Sensitive Detection of High-risk Bacterial Pathogens Using SERS-based ... file

저널명 Sensors & Actuators B, 270, 72-79 (2018) 

저자 Rui Wang, Kihyun Kim, Namhyun Choi, Xiaokun Wang, Jiyoung Lee, Jun Ho Jeon, Gi-eun Rhie and Jaebum Choo* 

기타사항  

2018 PEGylated Nanographene–mediated Metallic Nanoparticle Clusters for Surface En... file

저널명 Analyst, 143, 2604-2615 (2018) 

저자 Ahmed Ali , Eun Young Hwang , Jaebum Choo and Dong Woo Lim* 

기타사항  

2018 M13 Bacteriophage/Silver Nanowire Surface-Enhanced Raman Scattering Sensor fo... file

저널명 ACS Applied Materials & Interfaces, 10, 10388-10397 (2018) 

저자 Eun Hye Koh, ChaeWon Mun, Chun Tae Kim, Sung-Gyu Park, Eun Jung Choi, Sun Ho Kim, Jaejeung Dang, Jaebum Choo, Jin-Woo Oh, Dong-Ho Kim* and Ho Sang Jung* 

기타사항  

2018 Culture-free Detection of Bacterial Pathogens on Plasmonic Nanopillar Arrays... file

저널명 ACS Applied Materials & Interfaces, 10, 6831-6840 (2018) 

저자 Juhui Ko, Sung-Gyu Park, Sangyeop Lee, Xiaokun Wang, Chaewon Mun, Sunho Kim, Dong-Ho Kim* and Jaebum Choo* 

기타사항  

2018 Nanoscale graphene oxide-induced metallic nanoparticle clustering for surface-e... file

저널명 Sensors & Actuators B, 255, 183-192 (2018) 

저자 Ahmed Ali, Eun Young Hwang, Jaebum Choo and Dong Woo Lim* 

기타사항  


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