저널명 : Analytical Chemistry, 89, 1163-1169 (2017) 
저자 : Xiaokun Wang, Namhyun Choi, Ziyi Cheng, Juhui Ko, Lingxin Chen*, and Jaebum Choo* 
기타사항 :  

Abstract

A new class of surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor has been developed for the simultaneous detection of dual DNA markers. The LFA strip in this sensor was composed of two test lines and one control line. SERS nano tags labeled with detection DNA probes were used for quantitative evaluation of dual DNA markers with high sensitivity. Target DNA, associated with Kaposi’s sarcoma-associated herpesvirus (KSHV) and bacillary angiomatosis (BA), were tested to validate the detection capability of this SERS-based LFA strip. Characteristic peak intensities of SERS nano tags on two test lines were used for quantitative evaluations of KSHV and BA. The limits of detection for KSHV and BA, determined from our SERS-based LFA sensing platform, were estimated to be 0.043 and 0.074 pM, respectively. These values indicate approximately 10 000 times higher sensitivity than previously reported values using the aggregation-based colorimetric method. We believe that this is the first report of simultaneous detection of two different DNA mixtures using a SERS-based LFA platform. This novel detection technique is also a promising multiplex DNA sensing platform for early disease diagnosis.


Download PDF = Click Attachment, please.

List of Articles
제목 저널명 저자 기타사항

2017 Simultaneous detection of dual prostate specific antigens using SERS-based immun...

저널명 ACS Nano, in press. 

저자 Ziyi Cheng, Namhyun Choi, Rui Wang, Sangyeop Lee, Kyung Chul Moon, Soo-Young Yoon, Lingxin Chen* and Jaebum Choo* 

기타사항  

2017 From single-molecule detection to next-generation sequencing: microfluidic dro... file

저널명 Microfluidics and Nanofluidics, 21:58 (2017) 

저자 Yun Ding, Jaebum Choo and Andrew deMello* 

기타사항  

2017 Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy file

저널명 Chemical Society Reviews, 46, 2237-2271 (2017) 

저자 Min Gao, Fabiao Yu*, Changjun Lv, Jaebum Choo* and Lingxin Chen* 

기타사항  

2017 Quantum Dot–based Molecularly Imprinted Polymers on Three-Dimensional Origami ... file

저널명 ACS Sensors, 2, 243-250 (2017) 

저자 Bowei Li, Zhong Zhang, Ji Qi, Na Zhou, Song Qin, Jaebum Choo* and Lingxin Chen* 

기타사항  

2017 Spectroscopic measurements of interactions between hydrophobic 1-pyrenebutyric... file

저널명 Colloids and Surfaces A, 518, 295-303 (2017) 

저자 Nguyen Hoang Ly, Thanh Danh Nguyen, Thanh Lam Bui, Sangyeop Lee, Jaebum Choo, Sang-Woo Joo* 

기타사항  

2017 Raman spectrum identification based on the correlation score using weighted ... file

저널명 Analyst, 142, 380-388 (2017) 

저자 Jun-Kyu Park, Aaron Park, Si Kyung Yang, Sung-June Baek*, Joonki Hwang and Jaebum Choo* 

기타사항  

2017 Simultaneous Detection of Dual Nucleic Acids Using a SERS-based Lateral Flow... file

저널명 Analytical Chemistry, 89, 1163-1169 (2017) 

저자 Xiaokun Wang, Namhyun Choi, Ziyi Cheng, Juhui Ko, Lingxin Chen*, and Jaebum Choo* 

기타사항  

2017 Optical nanoprobes for ultrasensitive immunoassay file

저널명 Analytical Chemistry, 89, 124-137 (2017) 

저자 Xiuli Fu, Lingxin Chen* and Jaebum Choo* 

기타사항  

2017 Interfacial structures of 1-methyladenine, 3-methyladenine, 7-methyladenine, and... file

저널명 Journal of Molecular Structure, 1128, 215-220 (2017) 

저자 Dinh Bao Nguyen, Sang-Woo Joo* and Jaebum Choo* 

기타사항  

2017 Quantitative analysis of thyroid-stimulating hormone (TSH) using SERS-based later... file

저널명 Sensor and Actuators B, 240, 358-364 (2017) 

저자 Suji Choi, Joonki Hwang, Sangyeop Lee, Dong Woo Lim, Hoodon Joo, and Jaebum Choo* 

기타사항  


XE Login